- Abdul Hakim Murad, of al-Qaeda's Operation Bojinka[1]
- Accardo Simonelli, gangster from the New Mexico mafia. Hitman with more than 30 counts of murder.
- Adolph Reynoso, of the Mexican Mafia
- Ahmed Ajaj, of the 1993 World Trade Center bombing[2]
- Ahmed Omar Abu Ali, Al Qaeda conspirator in several plots, including one to assassinate U.S. President George W. Bush
- Ahmed Ressam, of the 2000 millennium attack plots[1]
- Alex Aguirre, of the Mexican Mafia
- Anthony "Gaspipe" Casso, 16802-050, former Underboss turned informant for the Lucchese crime family
- Anthony McBayne
- Anthony Jones, multiple murderer
- Antonio Guerrero Rodríguez, Cuban spy, serving life plus 10 years
- Aziz Abdul Mumi
- Barry Byron Mills, of the Aryan Brotherhood
- Bryan Cook serving a 40-year sentence for carjacking and assault, was stabbed while in the recreation yard
- Charles Harrelson, 02582-016, Texan hitman, convicted of murdering federal judge, father of actor Woody Harrelson, died in prison of a heart attack March 15, 2007.[3]
- Clement Rodney Hampton-El, a.k.a. Dr. Rashid, of the 1993 World Trade Center bombing
- Dandeny Muñoz Mosquera, chief assassin for Pablo Escobar, responsible for the bombing of Avianca Flight 203
- Danny Weeks, for kidnapping two women in the course of escaping from Louisiana Penitentiary at Angola[4][not in citation given]
- David Brian Stone was stabbed in the back while in the recreation yard. He was serving a 10-year sentence for firearm possession by a felon
- David Lane, 12873-057, white supremacist and racketeer. Died in his sleep 28 May 2007.
- David Roland Hinkson convicted in federal court for plotting to kill a federal judge, prosecutor and IRS agent who were involved in a tax case against him.
- David Vargas
- Douglas Black facing a life sentence for murder in Massachusetts in addition to his federal time a seven-year sentence for assault
- Douglas Saxon Taylor leader of the 88 Skinheads
- Dwight York, 17911-054, founder of the United Nuwaubian Nation of Moors serving 135 years for child molestation and racketeering[5]
- El Sayyid Nosair, of the 1993 World Trade Center bombing.[6]
- Eric Robert Rudolph, 18282-058, terrorist, committed the Centennial Olympic Park bombing and other bombings[1][7]
- Eyad Ismail, 37802-054, of the 1993 World Trade Center bombing[6][8]
- Frank Melendez, cocaine dealer from California killed in ADX Florence by Mirssa Araiza-Reyes
- Francisco Javier Arellano Felix, Mexican drug lord
- Garrett Wade Linderman Linderman had been in another prison for robbery until his cellmate there was found stabbed to death. Linderman wasn't tried for the murder, but they transferred him to the A.D.X.
- Gerald Rubalcaba, of the Nuestra Familia
- Gregory Scarpa Jr former Colombo Family member
- H. Rap Brown 99974-555, former civil rights activist convicted of murdering a Georgia sheriff's deputy (NOTE: Brown is a Georgia state inmate held here because Georgia does not have a suitable facility.)
- Hanif Shabazz Bey (Beaumont Gereau) # 295933
- Howard "Pappy" Mason 24651-053, drug trafficker who ordered the murder of police officer Eddie Byrne.
- Ibrahim Elgabrowny, of the New York City landmark bomb plot
- Iyman Faris, also of the NYC landmark plot, sentenced to 20 years in 2003
- James Curtis Martin was stabbed and strangled last April. He was serving a 95-year sentence for two counts of murder.
- James Ujaama, who tried to develop an al-Qaeda camp in Oregon
- Jeff Fort, he is currently imprisoned on drug trafficking charges. He is also the only American citizen ever convicted of terrorism for hire.[9]
- Joey Estrella, bank robber, killed in ADX Florence by the Sablan cousin's
- Joseph Wroblewski killed by Shane Patrick Bailey
- John Walker Lindh, dubbed "The American Taliban"[10]
- Jose Padilla, 20796-424, convicted of aiding terrorists
- Joseph Bryant McGee, bank robber
- Joseph Anthony Leissler, robber and murderer
- Juan Matta-Ballesteros, 37671-133, drug trafficker in the Enrique Camarena case, serving 480 years
- Khalfan Khamis Mohamed, participant in the 1998 United States embassy bombings
- Kojo Bomani Sababu, aka Grailing Brown convicted of bank robbery, part of the Black Liberation Army
- Kenneth "Supreme" McGriff 26301-053, an American drug trafficker and organized crime figure.
- Larry Hoover, 86063-024, leader of the Gangster Disciples gang in Chicago
- Lawrence Klaker He killed himself, Aryan Brotherhood member
- Luis Felipe, leader of the Latin Kings gang[11]
- Mahmud Abouhalima, of the 1993 World Trade Center bombing[12]
- Manuel Torrez, who in 2005 at age 64 became the first inmate to be murdered in a Supermax prison[13][14]
- Mark Jordan was convicted of bank robbery, and in 1999 he stabbed an inmate to death at the adjacent U.S. Penitentiary in Florence
- Matthew F. Hale, 15177-424, white supremacist for soliciting the murder of federal judge Joan Lefkow
- Maynard Campell, white separatist with ties to militia groups;serving a ten-year sentence stemming from a land dispute with federal officials in Orego, was stabbed to death
- Michael Swango, physician and serial murderer
- Mirssa Araiza-Reyes, drug smuggler and illegal alien; killed inmate Frank Melendez
- Mohamed Rashed Daoud Al-Owhali, of the 1998 U.S. embassy bombings
- Mohammed A. Salameh, of the 1993 World Trade Center bombing[12]
- Mohammed Ali Hassan Al-Moayad, would-be financier of al-Qaeda and Hamas, serving 75 years
- Mohammed Odeh is one of the four former al-Qaeda members sentenced to life imprisonment in 2001 for their parts in the 1998 United States embassy bombings.
- Mustafa Zulu
- Mutulu Shakur, 83205-012, serving 60 years for a bank robbery in which a policeman and two guards were killed. Stepfather of late rapper Tupac Shakur, brother of Assata Shakur[15]
- Nicodemo Scarfo, was serving life imprisonment at Supermax,[9] primarily on the testimony of a number of informants, including his nephew. He managed to overturn his life sentence and get transferred to an FCI in Atlanta, Georgia.
- Nidal Ayyad, of the 1993 World Trade Center bombing[12]
- Omar Abdel-Rahman, 34892-054, al-Gama'a al-Islamiyya mentor, nicknamed "The Blind Sheik", serving life for his part in the 1993 World Trade Center bombing
- Omar Mohammed Rezaq, airliner hijacker
- Omar Portee, aka O.G. Mack. Co-founder of the United Blood Nation
- Paul Chartier
- Peter Rollack Sex, Money, Murder founder is currently serving 105 years without parole for 6 murders
- Oscar Rivera, leader of the Armed Forces of National Liberation, a Puerto Rican militant group, for bombing 28 targets in the Chicago area. Received an additional 15-year sentence for an escape attempt (from another prison).
- Ramzi Yousef, 03911-000, of the 1993 World Trade Center bombing and Operation Bojinka, senior al-Qaeda member[13][16][11]
- Raymond Luc Levasseur, American domestic bomber
- Raymond Oechsle, was incarcerated with Casso from 2001 to 2002 at ADX
- Ramiro "Ramsey" R. Muñiz 40288-115 convicted of drug charges, political figure
- Richard Reid, 24079-038, al-Qaeda's would-be "Shoe Bomber"[17]
- Richard Lee McNair, 13829-045, escape artist, serving 3 life sentences for murder.[18][19][20]
- Richard Scutari, conspirator in a 1984 robbery of a Brink's armored truck; serving 60 years
- Robert Haney, bank robber, pretended to escape from ADX with Tony Francis
- Robert Hanssen, 48551-083, former senior FBI agent serving life for espionage[16]
- Robert Jones
- Rodney Hambrick, serving a 68-year sentence on bomb charges
- Ronald Griesacker, fraudster, passed $2 million in worthless checks. Released in 2002.
- Rudy Cabrera Sablan serving a 92-month sentence for being a felon in possession of a firearm. Also serving Life without parole in the killing of Joey Estrella.
- Ruben "Nite Owl" Castro, of the Mexican Mafia
- Salvatore "Sammy the Bull" Gravano, former Underboss turned government witness of the Gambino crime family[16]
- Terry Nichols, 08157-031, Oklahoma City Bombing conspirator[13]
- Shane Patrick Bailey bank robber from Minnesota, is charged with ending cellmate Joseph Wroblewski's life on May, 23, 1999
- Steven Riddle inmate who did most of the stabbing of Campbell, got ten years for manslaughter
- Theodore Kaczynski, 04475-046, the "Unabomber"[11]
- Thomas Silverstein, bank robber and murderer; killed guard Merle Clutts at United States Penitentiary, Marion[16]
- Timothy McVeigh, executed 2001 for Oklahoma City bombing[16][11]
- Tom Manning, political serial bomber, has been transferred to USP Hazelton
- Tony Francis pretended with Robert Haney to escape from ADX[citation needed]
- Tyler Davis Bingham, conspired to order multiple killings and assaults from Florence ADX
- Tyrone Love, transferred to Florence after the "crack riots" at Lompoc, California in 1996
- Wadih el-Hage, 42393-054, of the 1998 United States embassy bombings in Africa[21]
- Wali Khan Amin Shah Operation Bojinka
- Wayne Perry, henchman for The Alberto "Alpo" Martinez Drug Gang
- William Sablan serving a 252-month sentence for hostage taking, now serving life without parole, killing of Joey Estrella
- Yu Kikumura, of the Japanese Red Army, released April 18, 2007, served 221 months, deported[21]
- Zacarias Moussaoui, 51427-054, of the September 11, 2001 attacks[1]
- Zayd Hassan Abd Al-Latif Masud Al Safarini, Pan Am Flight 73 Hijacker
